Surgery is not life-prolonging

Surgery is not life-prolonging.
Fewer US colon cancer patients who are diagnosed in the settled stages of their infirmity are having what can often be unwanted surgery to have the primary tumor removed, researchers report. These patients are also living longer even as the surgery becomes less common, although their inclusive forecasting is not good. The findings disclose "increased recognition that the first-line treatment in is chemotherapy" for stage 4 colon cancer patients, said retreat co-author Dr George Chang, chief of colon and rectal surgery at the University of Texas MD Anderson Cancer Center in Houston view website. While removing the earliest tumor may be caring for some reasons "surgery is not life-prolonging".

With the patients in question, their cancer has expand from the intestines to other organs such as the liver or lung, in a activity called metastasis. In many cases, the prediction is death, one skilful not part of the study said. "Cure is not possible for most patients with metastatic colorectal cancer," said Dr Ankit Sarin, an helpmeet professor of surgery in the cut of colon and rectal surgery at University of California, San Francisco.

Twenty percent of patients diagnosed with colon cancer have situation 4 disease, according to curriculum vitae dope in the study. Cancer specialists and patients face a big call in after such a diagnosis: What treatment, if any, should these patients have? "The prime instinct is 'I want it out'". But removing the tumor from the colon may not be beneficial once cancer has spread, and "getting it out may back their ability to get treatment that's life-prolonging".

New Gene Mutations Linked To Colon Cancer

New Gene Mutations Linked To Colon Cancer.
Researchers who discovered novel gene mutations linked to colon cancer in clouded Americans order their findings could supervise to improved diagnosis and treatment. In the United States, blacks are significantly more favoured to develop colon cancer and to die from the infection than other racial groups. For the study, the researchers said they second-hand DNA sequencing to examined 50 million bits of text from 20000 genes seks. They said that determining gene mutations has been the driving pry behind all the new drugs created to take up cancer in the last decade.

So "Many of the new cancer drugs on the deal in today were developed to target specific genes in which mutations were discovered to cause certain cancers," study corresponding novelist Dr Sanford Markowitz, an expert in the genetics of cancer at Case Western Reserve University in Cleveland, said in a university report release. The investigators compared 103 colon cancer samples from sooty patients and 129 samples from milk-white patients treated at University Hospitals Case Medical Center in Cleveland.

Preparation For Colonoscopy As A Tablet Relieves Suffering From The Procedure

Preparation For Colonoscopy As A Tablet Relieves Suffering From The Procedure.
One goal many clan terrifying a colonoscopy is the unpleasant preparation, which often requires that they potable a gallon of prescribed fluids to clear out their bowels before the procedure. But an industry-funded con suggests that a pill could negate the prerequisite for so much liquid ubat leflunomide. Researchers from Henry Ford Hospital publish that people preparing for the test were able to take a pill approved as a curing for chronic constipation and avoid half of the liquid requirement.

In the study, 126 race took either the pill - lubiprostone (Amitiza) - or an inert placebo. Those who took the federation of the pill and liquid were better able to tolerate the preparation than were those who drank a gallon of a blend of polyethylene glycol and electrolytes, the study found. "Most forebears say they don't want to have a colonoscopy because they find the preparation intolerable," the study's assume command author, Dr Chetan Pai, a gastroenterologist, said in a news broadcast release from the hospital.

So "If physicians are able to present oneself a better way to prep, I think this will encourage more ladies and gentlemen to get the colonoscopies that may save their lives". Pai also pointed out that about 90 percent of colon cancer cases arise in people older than 50, an maturity group that tends to have an especially hard time drinking the gallon of melted often prescribed for colonoscopy preparation. The study, scheduled to be presented Sunday at the Digestive Diseases Week meeting in New Orleans, was funded by the pill's maker Sucampo Pharmaceuticals.

A colonoscopy is an internal cross-examination of the colon (large intestine) and rectum, using an thingummy called a colonoscope. How the Test is Performed. The colonoscope has a trivial camera attached to a bendable tube. Unlike sigmoidoscopy, which can only reach the lower third of the colon, colonoscopy examines the full length of the colon.

Statins Do Not Reduce The Risk Of Colon Cancer

Statins Do Not Reduce The Risk Of Colon Cancer.
Statins don't condescend the chance of colorectal cancer, and may even heighten the chances of developing precancerous polyps, green research suggests for more info. Statins are widely prescribed cholesterol-lowering drugs sold in a genre of generic forms and identify names, including Lipitor, Crestor and Zocor.

Yet, researchers stressed that the results are "not conclusive," and that bourgeoisie taking statins to tone down cholesterol and reduce their risk of heart attack should continue taking the drugs. "We found patients in this work taking statins for more than three years tended to reveal more premalignant colon lesions," said consider author Dr Monica Bertagnolli, chief of the division of surgical oncology at Brigham and Women's Hospital and a professor of surgery at Harvard Medical School. "This is an inviting declaration that needs to be followed up, but it should not bring up alarm. No one should stop taking their statins."

The survey is to be presented Monday at the American Association for Cancer Research annual convergence in Washington, DC, and it is also published online in the periodical Cancer Prevention Research. The data used in the enquiry was from an earlier clinical trial to determine if the cox-2 anaesthetic celecoxib (Celebrex) could be used to prevent colon cancer.

That effort included 2035 people who were at high risk of colon cancer and had already been diagnosed with precancerous polyps, or adenomas. That study, published in 2006, found the celecoxib reduced the incident of adenomas, but it also more than doubled the endanger of nub attack and other serious cardiac events.

Early Diagnostics Of A Colorectal Cancer

Early Diagnostics Of A Colorectal Cancer.
Researchers in South Korea bring up they've developed a blood evaluation that spots genetic changes that notify the shade of colon cancer, April 2013. The test accurately spotted 87 percent of colon cancers across all cancer stages, and also correctly identified 95 percent of patients who were cancer-free, the researchers said. Colon cancer remains the jiffy primary cancer triggerman in the United States, after lung cancer vigrx delay spray precio en minnesota. According to the US Centers for Disease Control and Prevention, nearly 137000 Americans were diagnosed with the malady in 2009; 40 percent of consumers diagnosed will stop from the disease.

Right now, invasive colonoscopy remains the "gold standard" for spotting cancer early, although fecal privy blood testing (using stool samples) also is used. What's needed is a warmly correct but noninvasive testing method, experts say. The budding blood investigation looks at the "methylation" of genes, a biochemical treat that is tone to how genes are expressed and function. Investigators from Genomictree Inc and Yonsei University College of Medicine in Seoul said they spotted a set of genes with patterns of methylation that seems to be delineated to tissues from colon cancer tumors.

Changes in one gene in particular, called SDC2, seemed especially tied to colon cancer tumour and spread. As reported in the July 2013 circulation of the Journal of Molecular Diagnostics, the yoke tested the gene-based divider in tissues enchanted from 133 colon cancer patients. As expected, tissues captivated from colon cancer tumors in these patients showed the earmark gene changes, while samples entranced from adjacent healthy tissues did not.

More important, the same genetic hallmarks of colon cancer (or their absence) "could be regulated in blood samples from colorectal cancer patients and thriving individuals," the researchers said in a almanac gossip release. The test was able to detect stage 1 cancer 92 percent of the time, "indicating that SDC2 is apt for inopportune detection of colorectal cancer where therapeutic interventions have the greatest probability of curing the patient from the disease," study precede author TaeJeong Oh said in the news release.

A New Factor Of Increasing The Risk Of Colon Cancer Was Studied

A New Factor Of Increasing The Risk Of Colon Cancer Was Studied.
Researchers report in that heinous levels of a protein monotonous through blood tests could be a badge that patients are at higher risk of colon cancer medisalic side ifat. And another unheard of study finds that in blacks, a common base boosts the risk of colorectal polyps - weird tissue growths in the colon that often become cancerous.

Both studies are slated to be presented Monday at the American Association for Cancer Research (AACR) annual congregation in Washington, DC. One research links spacy levels of circulating C-reactive protein to a higher gamble of colon cancer. Protein levels rise when there's low-grade redness in the body.

So "Elevated CRP levels may be considered as a peril marker, but not necessarily a cause, for the carcinogenic process of colon cancer," Dr Gong Yang, digging associate professor at Vanderbilt University, said in an AACR message release. Yang and colleagues forced 338 cases of colorectal cancer surrounded by participants in the Shanghai Women's Health Study and compared them to 451 women without the disease.

Women whose protein levels were in the highest point had a 2,5 - ply higher risk of colon cancer compared to those in the lowest quarter. In the other study, researchers linked the bacterium Helicobacter pylori to a higher imperil of colorectal polyps in blacks. That could up it more inclined to that they'll age colon cancer.

But "Not everyone gets nauseated from H pylori infection, and there is a legitimate concern about overusing antibiotics to probe it," said Dr Duane T Smoot, first of the gastrointestinal division at Howard University, in a statement. However, the manhood of the time these polyps will become cancerous if not removed, so we shortage to screen for the bacteria and treat it as a possible cancer interdicting strategy. The study authors, who examined the medical records of 1262 knavish patients, found that the polyps were 50 percent more extensive in those who were infected with H pylori.

New Non Invasive Test For Detection Of Tumors Of The Colon Is More Accurate Than Previously Used

New Non Invasive Test For Detection Of Tumors Of The Colon Is More Accurate Than Previously Used.
A imaginative noninvasive analysis to feel pre-cancerous polyps and colon tumors appears to be more exact than au courant noninvasive tests such as the fecal private blood test, Mayo clinic researchers say. The perusal for a highly accurate, noninvasive alternative to invasive screens such as colonoscopy or sigmoidoscopy is a "Holy Grail" of colon cancer research herbala.gdn. In a premonitory trial, the revitalized prove was able to identify 64 percent of pre-cancerous polyps and 85 percent of full-blown cancers, the researchers reported.

Dr Floriano Marchetti, an helpmeet professor of clinical surgery in the border of colon and rectal surgery at University of Miami Sylvester Comprehensive Cancer Center, said the supplemental study could be an important adjunct to colon cancer screening if it proves itself in further study. "Obviously, these findings call to be replicated on a larger scale. Hopefully, this is a right start for a more punctilious test".

Dr Durado Brooks, director of colorectal cancer at the American Cancer Society, agreed. "These findings are interesting. They will be more riveting if we ever get this accommodating of data in a screening population".

The study's flex researcher remained optimistic. "There are 150000 further cases of colon cancer each year in the United States, treated at an estimated bring in of $14 billion," noted Dr David A Ahlquist, professor of panacea and a consultant in gastroenterology at the Mayo Clinic in Rochester, Minn. "The illusion is to eradicate colon cancer utterly and the most realistic approach to getting there is screening. And screening not only in a approach that would not only detect cancer, but pre-cancer. Our try takes us closer to that dream".

Ahlquist was scheduled to file the findings of the study Thursday in Philadelphia at a meeting on colorectal cancer sponsored by the American Association for Cancer Research. The untrained technology, called the Cologuard sDNA test, mill by identifying circumscribed altered DNA in cells shed by pre-cancerous or cancerous polyps into the patient's stool.

If a DNA unconventionality is found, a colonoscopy would still be needed to back up the results, just as happens now after a firm fecal occult blood test (FOBT) result. To accept whether the test was effective, Ahlquist's team tried it out on more than 1100 frozen stool samples from patients with and without colorectal cancer.

The assess was able to scent 85,3 percent of colorectal cancers and 63,8 percent of polyps bigger than 1 centimeter. Polyps this extent are considered pre-cancers and most fitting to progress to cancer.

The Use Of Colonoscopy Reduces The Risk Of Colon Cancer

The Use Of Colonoscopy Reduces The Risk Of Colon Cancer.
In uniting to reducing the peril of cancer on the communist side of the colon, unknown research indicates that colonoscopies may also reduce cancer risk on the bang on side. The finding contradicts some previous research that had indicated a right-side "blind spots" when conducting colonoscopies scriptovore.com. However, the right-side further shown in the novel study, published in the Jan 4, 2011 go forth of the Annals of Internal Medicine, was slightly less capable than that seen on the left side.

And "We didn't really have good fettle data proving that anything is very good at preventing right-sided cancer," said Dr Vivek Kaul, acting superintendent of gastroenterology and hepatology at the University of Rochester Medical Center. "Here is a script that suggests that hazard reduction is pretty robust even in the precise side. The risk reduction is not as exciting as in the left side, but it's still more than 50 percent. That's a taste strong to ignore".

The news is "reassuring," agreed Dr David Weinberg, chairman of remedy at Fox Chase Cancer Center in Philadelphia, who wrote an accompanying think-piece on the finding. Though no one review ever provides definitive proof "if the data from this study is in act true, then this gives strong support for current guidelines".

The American Cancer Society recommends that normal-risk men and women be screened for colon cancer, starting at life-span 50. A colonoscopy once every 10 years is one of the recommended screening tools. However, there has been some controversy as to whether colonoscopy - an invasive and extravagant mode - is beyond preferable to other screening methods, such as flexible sigmoidoscopy.

Hispanic Men Are More Likely To Suffer From Polyps in Colon Than Women

Hispanic Men Are More Likely To Suffer From Polyps in Colon Than Women.
Among Hispanics, men are twice as reasonable as women to have colon polyps and are also more acceptable to have multiple polyps, a supplemental exploration in Puerto Rico has found. The researchers also found that the enquiry patients older than 60 were 56 percent more indubitably to have polyps than those younger than 60. Polyps are growths in the prominently intestine antehealth.com. Some polyps may already be cancerous or can become cancerous.

The chew over included 647 patients superannuated 50 and older undergoing colorectal cancer screening at a gastroenterology clinic in Puerto Rico. In 70 percent of patients with polyps, the growths were on the true surface of the colon. In wan patients, polyps are typically found on the left arrogance of the colon. This difference may result from underlying molecular differences in the two serene groups, said study author Dr Marcia Cruz-Correa, an friend professor of medicine and biochemistry at the University of Puerto Rico Cancer Center.

The pronouncement about polyp situation is important because it highlights the need to use colonoscopy when conducting colorectal cancer screening in Hispanics. This is the most productive pattern of detecting polyps on the right side of the colon. The sanctum was to be presented Sunday at the Digestive Diseases Week meeting in New Orleans.

Colonoscopy Decreases The Potential For Colorectal Cancer On The Right Side Of The Colon Also

Colonoscopy Decreases The Potential For Colorectal Cancer On The Right Side Of The Colon Also.
In joining to reducing the peril of cancer on the liberal interest of the colon, new research indicates that colonoscopies may also belittle cancer risk on the right side. The verdict contradicts some previous research that had indicated a right-side "blind spots" when conducting colonoscopies. However, the right-side further shown in the recent study, published in the Jan 4, 2011 end of the Annals of Internal Medicine, was slightly less effective than that seen on the socialist side. "We didn't really have robust data proving that anything is very attractive at preventing right-sided cancer," said Dr Vivek Kaul, acting prime of gastroenterology and hepatology at the University of Rochester Medical Center. "Here is a line that suggests that imperil reduction is pretty robust even in the right side medicine. The hazard reduction is not as exciting as in the left side, but it's still more than 50 percent.

That's a particle hard to ignore". The release is "reassuring," agreed Dr David Weinberg, chairman of pharmaceutical at Fox Chase Cancer Center in Philadelphia, who wrote an accompanying position statement on the finding. Though no one study ever provides final proof "if the data from this study is in fact true, then this gives weather-beaten support for current guidelines". The American Cancer Society recommends that normal-risk men and women be screened for colon cancer, starting at discretion 50.

A colonoscopy once every 10 years is one of the recommended screening tools. However, there has been some mull over as to whether colonoscopy - an invasive and precious modus operandi - is truly preferable to other screening methods, such as springy sigmoidoscopy. Based on a review of medical records of 1,688 German patients age-old 50 and over with colorectal cancer and 1,932 without, the researchers found a 77 percent reduced endanger for this quintessence of malignancy among people who'd had a colonoscopy in the before 10 years, as compared with those who had not.

The Overall Rate Of Colon Cancer Has Fallen

The Overall Rate Of Colon Cancer Has Fallen.
Although the overall reproach of colon cancer has fallen in up to date decades, untrained research suggests that over the wear 20 years the disease has been increasing among young and ahead middle-aged American adults. At issue are colon cancer rates all men and women between the ages of 20 and 49, a bundle that generally isn't covered by public well-being guidelines. "This is real," said study co-author Jason Zell, an helpmeet professor in the departments of medicine and epidemiology at the University of California, Irvine medrxcheck.com. "Multiple inspection organizations have shown that colon cancer is rising in those under 50, and our scrutiny found the same, particularly in the midst very young adults.

Which means that the epidemiology of this disease is changing, even if the autocratic risk among young adults is still very low". Results of the cramming were published recently in the Journal of Adolescent and Young Adult Oncology. The analyse authors noted that more than 90 percent of those with colon cancer are 50 and older. Most Americans (those with no people account or heightened risk profile) are advised to create screening at age 50.

Despite remaining the third most stale cancer in the United States (and the number two cause of cancer deaths), a sensible rise in screening rates has appeared to be the duct driving force behind a decades-long plummet in overall colon cancer rates, according to grounding information in the study. An analysis of US National Cancer Institute data, published mould November in JAMA Surgery, indicated that, as a whole, colon cancer rates had fallen by primitively 1 percent every year between 1975 and 2010.

But, that inspect also revealed that during the same adjust period, the price among people aged 20 to 34 had as a matter of fact gone up by 2 percent annually, while those between 35 and 49 had seen a half-percent once-a-year uptick. To examine that trend, the current study focused on information collected by the California Cancer Registry. This registry included poop on nearly 232000 colon cancer cases diagnosed between 1988 and 2009.

Vitamin D And Chemotherapy Of Colon Cancer

Vitamin D And Chemotherapy Of Colon Cancer.
Higher vitamin D levels in patients with advanced colon cancer appear to promote retort to chemotherapy and targeted anti-cancer drugs, researchers say. "We found that patients who had vitamin D levels at the highest sort had improved survival and improved progression-free survival, compared with patients in the lowest category," said chain maker Dr Kimmie Ng, an helper professor of drug at Harvard Medical School in Boston clovate. Those patients survived one-third longer than patients with plebeian levels of vitamin D - an customary 32,6 months, compared with 24,5 months, the researchers found.

The report, scheduled for conferring this week at the Gastrointestinal Cancers Symposium in San Francisco, adds more bias to suspicions that vitamin D might be a valuable cancer-fighting supplement. However, colon cancer patients shouldn't analyse to support vitamin D levels beyond the average range, one specialist said. The bone up only found an association between vitamin D levels and colon cancer survival rates. It did not authenticate cause and effect.

Researchers for years have investigated vitamin D as a budding anti-cancer tool, but none of the findings have been aggressively enough to warrant a recommendation, said Dr Len Lichtenfeld, stand-in chief medical police officer for the American Cancer Society. "Everyone comes to the same conclusion - yes, there may be some benefit, but we unqualifiedly need to learning it carefully so we can be certain there aren't other factors that make vitamin D seem better than it is.

These findings are interesting, and show that vitamin D may have a post in improving outcomes in cancer care". In this study, researchers premeditated blood levels of vitamin D in 1,043 patients enrolled in a point of view 3 clinical nuisance comparing three first-line treatments for newly diagnosed, advanced colon cancer. All of the treatments concerned chemotherapy combined with the targeted anti-cancer drugs bevacizumab and/or cetuximab.

Vitamin D is called the "sunshine vitamin" because hominoid bodies manufacture it when the sun's ultraviolet rays happen the skin. It promotes the intestines' talent to absorb calcium and other important minerals, and is indispensable for maintaining strong, healthy bones, according to the US National Institutes of Health. But vitamin D also influences cellular work in ways that could be advantageous in treating cancer.