Treatment Of Diabetes Is Different For Men And Women

Treatment Of Diabetes Is Different For Men And Women.
Widely employed diabetes drugs have distinct crap on men's and women's hearts, a untrained study suggests. Researchers examined how three commonly prescribed treatments for species 2 diabetes affected 78 patients who were divided into three groups. One categorize took metformin alone, the aid group took metformin additional rosiglitazone (sold under the brand name Avandia) and the third collect took metformin plus Lovaza, a type of fish oil pro extender v2 vs v3. Metformin reduces blood sugar manufacture by the liver and improves insulin sensitivity.

Rosiglitazone also improves insulin receptivity and moves set free fatty acids out of the blood. Lovaza lowers blood levels of another ilk of fat called triglycerides. The researchers found that the drugs had very several and sometimes opposite effects on the hearts of men and women, even as the drugs controlled blood sugar equally well in both genders. The investigate appears in the December version of the American Journal of Physiology - Heart and Circulatory Physiology.

Although metformin had unmitigated nucleus effects in women, it caused the resolution metabolism of men to burn less sugar and more fats. Chronic ablaze of fat by the heart results in harmful changes that can possibility to heart failure, said the researchers, from the Washington University School of Medicine in St Louis. "Instead of making feeling metabolism more general in men, metformin alone made it worse, looking even more such as a diabetic heart," study chief author Dr Robert Gropler said in a university copy release.

And "But in women, metformin had the desired effect - lowering rotundity metabolism and increasing glucose perceptiveness by the heart". Taking either rosiglitazone or Lovaza with metformin seemed to cut some of the negative heart effects of metformin alone in men. Taking rosiglitazone in summing-up to metformin further improved women's sensitivity metabolism, compared to taking metformin alone.

The addition of Lovaza to metformin did not have a better than average effect either way for men or women, the researchers said. "Our mull over suggests that we need to better define which therapies are optimal for women with diabetes and which ones are optimal for men," said Gropler, a professor of radiology. The ponder did not, however, verify a cause-and-effect component between the drug combinations and consideration changes vagina. It showed only an association.